Abstract Class B G protein-coupled receptors can form dimeric complexes important for high potency biological effects.Here, we apply pharmacological, biochemical, and biophysical techniques to cells and membranes expressing the prototypic secretin receptor (SecR) to gain insights into secretin binding to homo-dimeric and monomeric SecR.Spatial prox
Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation.Gene therapy for retinal conditions has led the Door Knockers way in this growing field.The loss of retinal ganglion cells (RGCs) is a hallmark of a number of retinal disorde
The advent of acid etching, introduced by Buonocore in 1955, brought the possibility of bonding between the bracket base and enamel, contributing to more esthetic and conservative orthodontics.This direct bracket bonding technique has brought benefits such as reduced cost and time Chopstick Rests in performing the treatment, as well as making it ea
The modern offshore Lawn Ornaments patrol vessel is designed to carry out various missions in the management of economic exclusion zones, thus having some speed of service.For example, the speed for slow patrol is 10 knots, regular patrols 18 knots and chasing 22 knots.This condition requires a flexible propulsion system, which is combination of me
Dynamic analysis of a rotor-bearing-pedestal system with multiple bearing clearances is conducted in this study.Firstly, Jones-Harris method is used to deduce the equivalent nonlinear support stiffness of angular contact high-speed ball bearing with preload considered.Ignoring the structural deformation, the contact model of inner and outer rings w